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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T28178 | NLRP3-IN-9 | INF-4E,INF 4E,INF4E | NOD |
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ... | |||
T9645 | CU-115 | N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide | TLR |
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells. | |||
T63140 | LSD1-IN-20 | Histone Demethylase | |
Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, w... | |||
T3502 | C29 | TLR | |
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. | |||
TN1879 | Lucideric acid A | Lucidenic acid A | MMP , p38 MAPK , JNK |
Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation. | |||
T4062 | CAY10602 | Sirtuin | |
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende... | |||
T1764 | Adezmapimod | PB 203580,RWJ 64809,SB203580 | Mitophagy , p38 MAPK , Autophagy |
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100... | |||
T9552 | BAZ1A-IN-1 | Epigenetic Reader Domain | |
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity ag... | |||
T14909 | CCX140 | CCX140-B | CCR |
CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2. | |||
T38328 | CU-32 | ||
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS ... | |||
T74718 | STING modulator-5 | ||
STING modulator-5 (compound 38), a STING modulator, exhibits a pIC50 value of 9.5 and antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. Additionally, it acts as an antagonist of THP-1 cells... | |||
T61405 | LSD1-IN-14 | ||
LSD1-IN-14, a powerful and specific inhibitor of LSD1 (with an IC50 value of 0.89 μM), effectively suppresses the growth of A549 and THP-1 cells and promotes the apoptosis of tumor cells [1]. | |||
T38329 | CU-76 | ||
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sens... | |||
T62659 | Cathepsin C-IN-4 | ||
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM). | |||
T63854 | Cathepsin C-IN-3 | ||
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM). | |||
T83901 | BDW568 | ||
BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value ... | |||
T72614 | STING modulator-3 | ||
STING modulator-3 is a STING inhibitor that effectively inhibits R232 STING, exhibiting a Ki value of 43.1 nM in scintillation proximity assays. Despite its inhibitory action on R232 STING, it does not affect IRF-3 activ... | |||
T28269 | ORY-1001 free base | RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016 | |
ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/do... | |||
T16614 | Propargyl-PEG4-acid | Others | |
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]... | |||
T72615 | STING modulator-4 | ||
STING Modulator-4 is a competitive modulator of STING, exhibiting a K_i value of 0.0933 μM for the R232H STING variant. It demonstrates an EC_50 of over 10 μM for p-IRF3 activation in THP-1 cells. |